Factors That May Influence Susceptibility to SARS-Cov-2: A Statistical Analysis

Click For Summary

Discussion Overview

The discussion revolves around the factors that may influence susceptibility to SARS-CoV-2, particularly focusing on the relationship between pre-existing immunity-related illnesses and COVID-19 outcomes. Participants explore statistical data, potential correlations, and the implications of immune system health on the severity of the disease.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • One participant inquires about the existence of statistics regarding patients with immunity-related illnesses and their susceptibility to SARS-CoV-2.
  • Another participant notes the lack of information on existing databases regarding immunity illnesses among COVID-19 patients and seeks expert contacts in immunity labs.
  • A participant references the historical context of hydroxychloroquine research related to autoimmune diseases as a relevant area of inquiry.
  • One contributor suggests that while immune suppression is generally accepted to increase risk, the complexity of immune responses complicates the understanding of risk factors, particularly in the elderly.
  • Another participant raises the question of whether patients had immunity issues prior to contracting SARS-CoV-2.
  • Several participants mention a specific study that discusses pre-existing conditions, including HIV, but express uncertainty about the broader implications for other immunity-related illnesses.
  • One participant speculates that the virus may impact immune competence itself, suggesting a potential feedback loop between the virus and immune health.
  • Another participant proposes that unknown factors may weaken the immune system, leading to increased lethality when infected with SARS-CoV-2.
  • One contributor emphasizes the multitude of individual and environmental factors that could influence susceptibility to infections, complicating the identification of clear risk factors.

Areas of Agreement / Disagreement

Participants express a range of views, with no consensus on the specific impact of immunity-related illnesses on SARS-CoV-2 susceptibility. There is acknowledgment of the complexity of immune responses and various factors that may influence risk, but no definitive conclusions are reached.

Contextual Notes

Participants note limitations in available data regarding immunity-related illnesses and their correlation with COVID-19 outcomes. The discussion highlights the need for further research and data collection to clarify these relationships.

hagopbul
Messages
397
Reaction score
45
TL;DR
There is few information regarding statistics I couldn't find on the net
Hello all:

Hope all are fine and well , there is this question in relation to corona virus problem :

Do anyone checked if the patients have any immunity related illnesses with the patients of SARS-Cov-2

Where I can find those statistics

Best regards
Stay safe
 
Biology news on Phys.org
no information on the site if the patients had some kind of immunity illness or they took an immunity illness tests during the SARS-COV-2 period

do you know an expert working in an immunity lab i can correspond with ?
 
Wasn't the auto-immune disease question the reason for folks looking at Hydroxychloroquine ? I believe that is what you should research...people are already looking.
 
  • Like
Likes   Reactions: hagopbul
I don't think such figures would be considered useful. It is generally accepted that immune suppression puts someone at increased risk, and the people involved are aware of this and could be expected to be taking extra precautions. It is assumed one of the reasons the elderly are more at risk is because their immune system is less effective. However this is complicated by the idea that a significant cause of death is due to an immune over response, which is currently treated with drugs designed to suppress this response.
I suspect that because of the actions to protect the immune compromised individuals and the delays in treatments that would cause immune suppression, if we treat the elderly as belonging to a different risk category, the numbers would be low and unrepresentative.
We might get some more information when they start reporting on vaccine trials but until then I suspect that any information will be based on theoretical risks.
 
  • Like
Likes   Reactions: BillTre and hagopbul
i was wondering if the patients had an immunity problem before SARA-Cov-2
 
  • Like
Likes   Reactions: hagopbul and Laroxe
atyy said:
This paper mentions problems that patients had before COVID-19. A small number of patients had HIV (not sure if that is the sort of immunity problem you were asking about):
https://jamanetwork.com/journals/jama/fullarticle/2761044

no i wonder if there is other immunity related thing that results in the fatality of SARS-COV-2
the fatality of this illness is 3.4 - 14%
could there is some sort of immune illness that make the SARS-COV-2 dangerous, some illness we don't know about ? if you don't test the patient blood will not be seen ?

hope all of you are safe and fine
 
Last edited:
  • #10
what if 1st was the immune system was weaken for reasons we don't know then if the SARS-cov-2 hit the person it became lethal , like the SARS-Cov-2 lethality is an outcome of some immune system illness
 
  • #11
Well there are lots of individual differences in people which might alter a persons susceptibility to any infection and then a huge set of environmental issues that might alter risk, so unless there is a clear single issue identified, like diabetes it will be impossible to get a clear answer.
So, yes immune competence is extremely important but there is a big list of things that might effect that.
 

Similar threads

  • · Replies 0 ·
Replies
0
Views
2K
Replies
7
Views
2K
  • · Replies 1 ·
Replies
1
Views
2K
  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 10 ·
Replies
10
Views
4K
  • · Replies 4 ·
Replies
4
Views
2K
  • · Replies 93 ·
4
Replies
93
Views
18K
  • · Replies 3 ·
Replies
3
Views
2K
Replies
1
Views
1K
Replies
1
Views
2K