Freezing of blood. What happens to it?

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    Blood Freezing
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Discussion Overview

The discussion revolves around the effects of freezing on whole blood, particularly in the context of conducting spectroscopy. Participants explore potential chemical differences between frozen blood and blood at room temperature, as well as the implications for experimental results.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested
  • Experimental/applied

Main Points Raised

  • One participant questions whether freezing blood alters its chemical composition and if it destroys elements of blood.
  • Another participant explains that freezing causes ice crystals to form, which may damage blood cells, but this damage may not be evident until the blood is thawed.
  • A participant notes that while freezing may kill blood cells, the proteins and molecules in blood might not change significantly, although the density of ice differs from that of water.
  • One reply mentions that clinical frozen blood typically does not have burst blood cells due to the addition of glycerol, which is used to prevent damage during freezing.
  • Another participant highlights that donated whole blood may undergo processing to remove certain components, which could affect spectroscopy results.

Areas of Agreement / Disagreement

Participants express differing views on the extent of damage caused by freezing blood cells and the implications for spectroscopy. There is no consensus on whether the changes in blood due to freezing will significantly impact the experimental outcomes.

Contextual Notes

Some assumptions about the effects of freezing on blood components are not fully explored, and the discussion does not resolve the potential impact of added chemicals in processed blood on spectroscopy results.

evidenso
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Hey
I have to do some spectroscopy of whole blood. But I can only get freezed blood. Is freezed blood different from 20 degree blood. Any chemical differences? does freezing destroy elements of blood.

regards
MB
 
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Hi evidenso,

Blood consists of about 50% water, and the rest are blood cells. Freezing the water will cause ice crystals to form, which will subsequently kill the blood cells (kinda like ice shards popping balloons). However, this won't be apparent until you thaw the blood.

If you're doing spectroscopy, the actual proteins, blood cells and molecules probably won't change much, but ice does have slightly different density to water. What kind of spectroscopy are you doing?
 
jaseh86 said:
Hi evidenso,

Blood consists of about 50% water, and the rest are blood cells. Freezing the water will cause ice crystals to form, which will subsequently kill the blood cells (kinda like ice shards popping balloons). However, this won't be apparent until you thaw the blood.

If you're doing spectroscopy, the actual proteins, blood cells and molecules probably won't change much, but ice does have slightly different density to water. What kind of spectroscopy are you doing?

OK thanks.
I have to do Raman spectroscopy of the blood. By killing the bloodcells, does they only "pop"?, bacause i need the same (or almost the same) scattering conditions from them as in whole blood
 
Clinical frozen blood doesn't have burst blood cells - otherwise it wouldn't be much use to the patient, glycerol is added to stop this
But donated whole blood may still have been processed to remove white blood cells and plasma, also a few chemicals are added to stabilise it which might have an effect on your results.
 
jaseh86 said:
Hi evidenso,

Blood consists of about 50% water, and the rest are blood cells. Freezing the water will cause ice crystals to form, which will subsequently kill the blood cells (kinda like ice shards popping balloons). However, this won't be apparent until you thaw the blood.

If you're doing spectroscopy, the actual proteins, blood cells and molecules probably won't change much, but ice does have slightly different density to water. What kind of spectroscopy are you doing?

THANK YOU jaseh86
 

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