Genes that Cause Human Aging: Telomeres, Klotho & Methuselah

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SUMMARY

The discussion centers on the genetic factors influencing human aging, specifically highlighting the roles of telomeres, Klotho, and Methuselah. It establishes that while telomere shortening is widely recognized as a primary aging mechanism, other genes like Klotho and Methuselah also significantly contribute to the aging process. Additionally, the accumulation of errors during cell division is identified as a critical factor leading to cellular dysfunction and tissue degeneration, which are essential aspects of aging. The conversation emphasizes the complexity of aging and the interplay of various genetic elements.

PREREQUISITES
  • Understanding of telomere biology and its role in cellular aging.
  • Knowledge of the Klotho gene and its implications in longevity.
  • Familiarity with the Methuselah gene and its association with lifespan.
  • Basic concepts of cellular division and DNA damage mechanisms.
NEXT STEPS
  • Research the role of telomeres in aging and potential therapies targeting telomere lengthening.
  • Explore the functions of the Klotho gene in age-related diseases and longevity.
  • Investigate the Methuselah gene and its impact on lifespan extension in various organisms.
  • Study the mechanisms of DNA damage repair and their relevance to cellular aging.
USEFUL FOR

Geneticists, biogerontologists, researchers in aging studies, and anyone interested in the molecular mechanisms of aging and longevity.

pomkon
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What genes cause aging, most people think shortening of telomeres is the main reason of aging, but I know there are more than that, like Klotho, Methuselah. But which fews are more important than others, and what else are there?
 
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Don't forget the long standing theory that accumulation of errors in cell division which causes their failure is responsible for much of the aging.
 
You mean that the DNA of the cells have been damaged so mush that it stops dividing, and when a lot of them are dying at the same time, the tissues are losing its phsiological function, and age? BUt why do you say for much of the aging?
 
That's what I meant, yes, sorry if I expressed it awkwardly. With "much of the aging" I meant to say that it's been considered an important cause, although I wouldn't know just how important.
 

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