1st question: Possibly. It's really interesting stuff, but it's not very main stream so if you work exclusively in it your work may be completely ignored by the larger physics community. And that's if you can even get it published. David Hestenes has had a lot of trouble getting his papers published (might be easier now, now that more people are working on it).
2nd question: Basically any geometric approach, including differential geometry (which is essentially completely contained in GA), allows you to work without reference to a specific coordinate frame. Calculating rotations is super easy in GA compared to vector arithmetic. Also, all of vectors, tensors, linear algebra, forms, quaternions, octonions, complex variables, etc. are all contained in the formalism of GA in some form or another. This makes it so that virtually all of physics can be worked in in terms of just GA. e.g. vector calculus works fine in E&M and classical mechanics, but it won't work for GR (you need more complicated tensor stuff). If you work with GA, you only need GA.
Simple example of GA vs. vectors: How many equations do you need for E&M? With vectors you need 4. With GA you only need 1.