Help: Nernst and reversal potentials

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SUMMARY

The discussion focuses on calculating the reversal potential and Nernst potential for ions, specifically sodium (Na+), potassium (K+), and chloride (Cl-), given their intracellular and extracellular concentrations. The Nernst equation is essential for determining the equilibrium potential for each ion, while the Goldman equation can be used to find the reversal potential for a membrane permeable to multiple ions. The specific concentrations provided are 5 mM Cl-, 130 mM K+, 20 mM Na+, and 10^-4 mM Ca2+ inside the cell, with corresponding external concentrations of 150 mM Cl-, 5 mM K+, 140 mM Na+, and 2 mM Ca2+.

PREREQUISITES
  • Understanding of the Nernst equation for calculating equilibrium potentials.
  • Familiarity with the Goldman equation for determining reversal potentials.
  • Knowledge of ion concentrations in biological systems.
  • Basic concepts of membrane permeability and ion conductance.
NEXT STEPS
  • Study the Nernst equation in detail to calculate individual ion potentials.
  • Learn how to apply the Goldman equation for mixed ion conductance scenarios.
  • Research the physiological significance of reversal potentials in neuronal signaling.
  • Explore the impact of ion concentration gradients on membrane potential.
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Students and professionals in physiology, neuroscience, and biochemistry, particularly those interested in membrane potentials and ion transport mechanisms.

madbeemer
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I know the following
ion/inside cell/outside cell
Cl- 5mM 150 mM
K+ 130mM 5mM
Na+ 20mM 140mM
Ca2+ 10^-4mM 2mM

How would I find the reversal potential for conductance equally permeable to sodium and potassium?
How do I find the reversal potential for a conductance equally permeable to sodium, potassium, and chlorine?
Also, how do I find the nernst potential for each ion at the below external and internal concentrations?
 
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