How do I add S/R configuration to this?

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SUMMARY

The discussion focuses on determining the S/R configurations of chiral centers in organic compounds. The procedure involves assigning priority to substituents based on atomic number and orienting the molecule so that the lowest priority group (#4) is facing away. If the arrangement of the higher priority groups (#1-3) is clockwise, the configuration is R; if counterclockwise, it is S. The discussion emphasizes the importance of visualizing the molecule, suggesting the use of physical models for clarity.

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  • Understanding of chiral centers in organic chemistry
  • Familiarity with Cahn-Ingold-Prelog priority rules
  • Basic skills in molecular visualization techniques
  • Knowledge of stereochemistry concepts
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Chemistry students, organic chemists, and anyone involved in stereochemical analysis or molecular modeling will benefit from this discussion.

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Edit by Mentor: thread moved from the other forum, hence no template used.

IMG_20170211_115259.jpg


The problem tells me to determine the S/R configurations of each chiral center in the compound, which I have drawn in the picture above. As you can see the numbers assigned by atomic # are not in order. How would I go about determining configuration in this case?
 
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Follow the procedure described here: http://web.chem.ucla.edu/~harding/tutorials/stereochem/r_s.html (you've already completed step #1, not just move onto steps #2 and 3).

Basically, you rotate the molecule so that the group with the lowest priority (#4) is pointing away from you. Then you look at the arrangement of the groups with priority #1-3. If these are arranged in a clockwise manner (i.e. you move clockwise going form #1 to #2 to #3) then the stereocenter is R. If they arranged in a counterclockwise manner, then the stereocenter is S.

If you have trouble visualizing and rotating the stereocenter in your head, try building a physical model that you can rotate for yourself.
 
following on from what was said previously, you've basically already done it with your drawing, as the H (lowest priority group) is pointing away from you.
 

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