How Do Molecules Pass Through Fenestrated Capillaries?

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SUMMARY

Fenestrated capillaries contain pores in the endothelial cells that facilitate the passage of molecules. These pores are not covered by a lipid membrane, allowing for selective permeability. Molecules pass through the basal lamina after traversing the endothelial pores, which is crucial for nutrient and waste exchange in tissues. Understanding this mechanism is essential for comprehending microcirculation and tissue perfusion.

PREREQUISITES
  • Basic knowledge of cellular biology and anatomy
  • Understanding of endothelial cell structure
  • Familiarity with the concept of basal lamina
  • Knowledge of molecular transport mechanisms
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  • Research the structure and function of endothelial cells in detail
  • Study the role of basal lamina in tissue physiology
  • Explore molecular transport mechanisms across cell membranes
  • Investigate the differences between continuous, fenestrated, and sinusoidal capillaries
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Students and professionals in biology, medicine, and healthcare who are interested in vascular biology, microcirculation, and the mechanisms of nutrient exchange in tissues.

sameeralord
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Hello everyone,

In fenestrated capillary there are holes inside the endothelial cell, I don't understand how cells can have holes? Does this mean that individual holes in endothelial cells are covered by a lipid membrane? Can anyone tell how can there be holes in an individual cells when lipid membrane usually covers the whole cell. Thanks :smile:

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simple_squamous_capillary.jpg


Now I realized each capillary is covered by a basal lamina, now how do the molecules pass through this after they pass through the pores?
 

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