How Do Pseudoknots in Viral RNA Trick Human Cells into Producing Viral Proteins?

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SUMMARY

The discussion centers on how viral RNA, particularly with structures known as pseudoknots, manipulates human ribosomes to produce viral proteins. Researchers have established that when a virus invades a human cell, its RNA mimics human RNA, allowing ribosomes to mistakenly translate it. The presence of pseudoknots causes ribosomes to occasionally slip backwards, leading to the synthesis of proteins that are essential for viral replication, such as those seen in HIV. This mechanism highlights the sophisticated strategies viruses employ to hijack cellular machinery for their own benefit.

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  • Familiarity with viral replication processes
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This discussion is beneficial for molecular biologists, virologists, and researchers focused on viral pathogenesis and protein synthesis mechanisms.

Edgardo
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The article Danish researchers solve virus puzzle
here
describes how physicists and biologists work together to examine how viruses are produced by a cell.

As far as I understand, every human cell has RNA which contains the 'recipe' on how to build proteins. The human cell also contains ribosomes that read the RNA and produce proteins.

Now, the virus invades the cell, leaves its RNA in the cell. The trick: because the viral RNA resembles the human RNA, the ribosomes read the viral ribosomes and produce proteins for the construction of a virus.

But the viral RNA has in contrast to the human RNA some curls, called pseudo-knots. The ribosomes have to unravel the pseudo-knot first. While doing this, they sometimes slip backwards such that the recipe is read in a different way.

Now my question about the following passage in the article:
During this process the ribosome sometimes slips backwards and, like the letters making up a word, it now reads a new RNA sequence and hence uses another recipe to construct the protein. The researchers have found that the stronger the pseudoknot the more often this backwards slipping happens. The different protein formed is the protein needed by the virus, with possible serious consequences for the hosting organism. This is the manner in which many vira, e.g. HIV, trick the cell into producing something which it never would have done otherwise.

I wonder about the sentence The different protein formed is the protein needed by the virus. Why can this different protein also be used to construct the protein?
 
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Oops, my question is of course:
Why can this different protein also be used to construct the virus?
 

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