How does the body regulate insulin secretion based on absorbed nutrients?

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SUMMARY

The regulation of insulin secretion in response to absorbed nutrients is primarily influenced by the liver's Glut2 transporters, which operate independently of insulin. When glucose is absorbed from the small intestine via the hepatic portal vein, the liver converts a portion into glycogen, while some is transformed into triglycerides, and the remainder is released into the bloodstream. The exact mechanisms determining the proportions of glucose and triglycerides released are not fully understood, but they significantly impact blood glucose levels and weight management.

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  • Understanding of insulin secretion mechanisms
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kyrani99
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If all of the absorbed glucose travels from the small intestine via the hepatic portal vein to the liver how does the body know how much insulin to secrete for the liver to convert the glucose to glycogen? Does some absorbed nutrient go via the pancreas?
 
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I'm sorry you are not generating any responses at the moment. Is there any additional information you can share with us? Any new findings?
 
Hi Greg, yes I have made some discoveries recently. The liver has Glut2 transporters which do not need insulin. But I still got a query. The liver will make some of the glucose into glycogen and store it, which is expected. And some is turned into triglycerides. The rest will be put into the blood stream as glucose. I still don't know how it decides what proportions of glucose and triglycerides it will put into the blood stream. Obviously not all of the glucose we eat and is absorbed goes into the blood stream. This can have a bearing on whether the person ends up with high glucose levels or puts on extra weight.
thank kyrani.
 

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