Welcome to the forum.
On a detailed level, of course there is variation in pressure. You experience this fairly directly even in such relatively minor changes as between standing upright and laying down.
However, the blood vessels are not passive pipes. They have a fairly sophisticated system of muscles and valves. When they are working correctly they help the blood flow move along, and keep the pressure regulated. Arteries tend toward having linings of muscle to help flow along. Veins tend toward having valves that help prevent backward flow. You can see what happens when these are not working properly if you google up varicose veins.