The area of a circle can be calculated using calculus by integrating the function that describes the circle's radius. By dividing the circle into quarters and manipulating the segments, one can approximate the area as a rectangle with dimensions related to the circle's radius and circumference. The integration can be simplified using polar coordinates, leading to the formula A = πR². Additionally, the equation of a circle in Cartesian coordinates can be used to find the area of a quarter circle and then multiplied by four for the total area. Overall, calculus provides a method to derive the area of a circle, confirming the established formula.