Copying large equations from Mathematica to MathType in Word can be problematic due to size limitations in MathType. Users are encouraged to follow specific instructions for copying and pasting, but if the equation exceeds the size limit, breaking the equation into smaller parts may be a viable workaround. This can involve separating the equation into components, such as the left and right sides of an equation. Additionally, users can try copying the equation as MathML, pasting it into Notepad, and then saving it for further use. This approach may help in managing the size issue while still allowing for the inclusion of complex equations in supplementary materials for publications.