High blood pressure, affecting over 1 billion people globally, is linked to severe health issues such as heart attacks and strokes. Research led by David Harrison at Vanderbilt University indicates that administering the hormone angiotensin II to mice induces hypertension, while the addition of the molecule 2-HOBA in their drinking water significantly normalizes blood pressure. This discovery suggests a potential new treatment avenue for hypertension in humans, although the effectiveness may vary based on the underlying causes of high blood pressure in different populations.
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No one treatment can control it in all cases.More than 1 billion people worldwide have high blood pressure, which promotes heart attacks, strokes, kidney damage, dementia, and other ailments.
It's fairly easy to give mice hypertension. Just regularly dose them with the hormone angiotensin II. But mixing a molecule called 2-HOBA into the animals' drinking water returns their blood pressure almost to normal, vascular biologist David Harrison of the Vanderbilt University School of Medicine in Nashville and colleagues have found. Now, that observation could open an innovative approach to treating hypertension in people.