Why Don't NAD+ Levels Increase Significantly in Humans?

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SUMMARY

NAD+ levels do not significantly increase in humans despite the effectiveness of precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) in mice. Research indicates that various strategies to boost NAD+ levels have shown positive outcomes in preclinical settings, yet translating these findings to humans remains challenging. The review by Katsyuba et al. (2020) highlights the complexities of NAD+ biochemistry and metabolism, emphasizing the need for further exploration into effective NAD+ boosters for enhancing healthspan and lifespan.

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  • NAD+ biochemistry
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Researchers, healthcare professionals, and individuals interested in the implications of NAD+ levels on health and aging will benefit from this discussion.

LightningInAJar
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TL;DR
Can NAD+ conversion in humans be increased?
As I understand it only in mice do precursors like nmn and nr readily get turned into NAD+ in the cells. But not so much in humans? What keeps NAD+ levels from increasing in people in any meaningful way?
 
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I googled and found:

https://www.semanticscholar.org/paper/NAD+-homeostasis-in-health-and-disease.-Katsyuba-Romani/9970f02833257350da64318d54e075c203701c69
NAD+ homeostasis in health and disease
Elena Katsyuba, Mario Romani, Dina Hofer and Johan Auwerx
Nature metabolism 2:9–31 (2020)
"In preclinical settings, various strategies to increase NAD+ levels have shown beneficial effects, thus starting a competitive race to discover marketable NAD+ boosters to improve healthspan and lifespan. Here, we review the basics of NAD+ biochemistry and metabolism, and its roles in health and disease, and we discuss current challenges and the future translational potential of NAD+ research."
 
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