Ion Flow Through a Channel: Current and Charge

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SUMMARY

The discussion focuses on calculating the current and charge of sodium ions flowing through a cylindrical ion channel with a diameter of 0.85 µm and a length of 5 µm, under a potential difference of 225 mV. The drift velocity is given as 0.015 m/s, and it is established that a total of 15 million ions exit the channel in 1 ms. The total charge exiting the channel is calculated to be 2.4 pC, while the current is initially miscalculated as 7.2 nA, but the correct value is confirmed to be 2.4 nA based on the time interval of 1 ms.

PREREQUISITES
  • Understanding of basic electrostatics and ion flow
  • Familiarity with the equations for charge (Q=qnV) and current (I=Q/t)
  • Knowledge of drift velocity and its implications in ion transport
  • Ability to perform calculations involving cylindrical geometry and volume (V=πr²h)
NEXT STEPS
  • Study the relationship between current density and drift velocity in ion channels
  • Learn about the effects of potential difference on ion flow in cylindrical channels
  • Explore the concept of charge density and its relevance in biological systems
  • Investigate the role of time intervals in calculating current and charge in electrochemical systems
USEFUL FOR

This discussion is beneficial for students in physics or biophysics, particularly those studying ion transport mechanisms, as well as educators and researchers interested in the electrical properties of ion channels.

GBC
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Sodium ion flows a through a cylindrical ion channel --> diameter = 0.85 um and is 5 um long.
potential difference b/w the ends of the channel is 225 mV
drift velocity = 0.015 m/s
in a period of 1 ms, a total of 15*10^6 ions exit the channel


a. total charge exiting the channel in 1 ms =?
b. current in the ion channel=?
i have been trying to find b.) but I think my values might be wrong... PLEASE HELP ME!

Homework Equations


Q=qnV
I=qnAv=Q/change in time
change in time = length/drift velocity
n=N/Vso for a. using the formula for Q:
q=1.6*10^-19
N=15*10^6
V=l*PIr^2= (5 um)(PI)(4.25*10^-7)^2=2.8*10^-18
plugging in this value to the equation of Q, I get:
Q=2.4*10^-12 (acc to the solutions on the book, this is right)

Now, my problem is b...
in this part, I used I=Q/t
i know t = length/velocity so i plug in giving me =(5 um)(0.015 m/s)
so now that i have t, i just use the Q from a to solve for I and I get 7.2*10^-9.
however, according to the solutions this is wrong. it is suppose to be 2.4*10^-9...
I have a feeling my Q value for this question is wrong since it's asking for the current IN the ion channel and the Q-value i have is the total charge exiting the channel... so how do I find the Q IN the ion channel??
please help me..!
 
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You were given the time interval over which the stated number of ions exited the channel. It was 1 ms. That's the timeframe that is important for figuring the current.

The drift velocity and channel dimensions are related to the current density. The time for a given ion to traverse the channel is not so important when there are many, many ions in a cross-section of the channel.
 
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Oh Thank you so much! I have never taken physics back in high school so this is all new to me. I was sort of confused on what it meant by "period of 1 ms" (I thought it was a typo for m/s... I have never seen millisecond used before haha) so thank you for explaining it! :)
 

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