Moonbear
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leroyjenkens said:That's interesting, thanks for the link.
Do you have any information on how severely it effects the person's weight?
From what I understand, it causes them to basically just eat more? Which means they just feel hungrier more often?
I knew there were genes involved, I'm just skeptical of how causative they are in someone being overweight.
There's more than one of these satiety hormones and receptors. It's not so much feeling hungrier more often as not feeling satisfied enough to stop eating. Leptin is best known because of those ob/ob mice, which show such a striking effect of genetics on body size. The mice in the picture shown are matched for age and food availability. Another major one being studied is adiponectin. There is also orexin, neuropeptide Y (which has 5 different receptor isoforms), thyroid hormones (long known for affecting metabolic rate). A fairly new arrival on the scene is nesfatin.
So, there can be a genetic component that comes from any of a large variety of hormones and signalling molecules. Alternatively, just as diabetes has an acquired form, so may obesity. So, just as you can permanently screw up your insulin receptors by being obese for a long time or since an early age, it is possible you can screw up your leptin receptors (leptin insensitivity) or any other of these receptors, if you start out overweight from an early age, and may get to the point where it does not matter how much you want to lose weight, you've already broken that regulatory system. This is of rising concern with the increase in childhood obesity. Children really don't know better, so if their parents allow them to be obese and don't help them regulate their diet when young, they really may be set up for life-long problems that will not be reversible once older.
