Ligand Charge Density: PEG-COOH vs. PEG-OH

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SUMMARY

The discussion centers on the comparison of ligand charge density between PEG-COOH and PEG-OH for Au-citrate nanoparticles. Participants conclude that PEG-COOH exhibits a higher anionic charge density due to the greater acidity of carboxylic acid compared to alcohol. Additionally, considerations such as pH and the molecular weight of PEG are crucial for successful phase transfer of citrate-capped nanoparticles.

PREREQUISITES
  • Understanding of ligand chemistry, specifically carboxylic acids and alcohols
  • Knowledge of nanoparticle phase transfer techniques
  • Familiarity with pH effects on ligand behavior
  • Basic principles of molecular weight and its implications in chemical reactions
NEXT STEPS
  • Research the phase transfer methods for citrate-capped nanoparticles
  • Study the impact of pH on ligand charge density
  • Explore the properties and applications of PEG-COOH in nanoparticle synthesis
  • Investigate the relationship between molecular weight and ligand efficacy
USEFUL FOR

Researchers in nanoparticle synthesis, chemists focusing on ligand interactions, and professionals involved in materials science and surface chemistry.

GGdog0818
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I want to exchange my Au-citrate nanoparticle with two kinds of ligands :PEG-COOH and PEG-OH.
Which one is suppose to have more anionic charge density.
 
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The carboxylic acid is more acidic than the alcohol. I vote COOH more anionic.

How are you doing the phase transfer? i have done some phase transfer on citrate capped nanoparticles.
 
I agree with Hyo X but don't forget to consider pH and PEG's molecular weight!
 

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