Myelin Conduction: Explaining Depolarization & Current Sinks

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SUMMARY

The discussion centers on the phenomenon of saltatory conduction in myelinated axons, where depolarization occurs at nodes of Ranvier, allowing electrical impulses to jump between these nodes. Myelin serves as an insulator, preventing current from passing through its sheath, which minimizes charge leakage and enhances conduction efficiency. The nodes function as capacitors, enabling rapid repolarization and transmission of signals along the axon. This mechanism significantly increases the speed of nerve impulse propagation compared to unmyelinated fibers.

PREREQUISITES
  • Understanding of saltatory conduction in neuroscience
  • Knowledge of myelin structure and function
  • Familiarity with the concept of nodes of Ranvier
  • Basic principles of electrical impedance in biological systems
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  • Research the mechanisms of saltatory conduction in detail
  • Explore the role of nodes of Ranvier in nerve signal transmission
  • Study the electrical properties of myelin and its impact on nerve conduction velocity
  • Investigate the differences between myelinated and unmyelinated axons
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Neuroscientists, biology students, and anyone interested in the mechanisms of nerve impulse transmission and the role of myelination in enhancing neural communication.

sameeralord
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Hello everyone,

I don't understand how depolarisation jumps when axons are myelinated. Ok myelin is an insulator so in that section no current passes through. But how does that make the current jump, when current reached myelin wouldn't it be inhibited, why does it still travel. Also what do they mean by developing current sinks at nodes of ranvier. Thanks :smile:
 
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sameeralord said:
Hello everyone,

I don't understand how depolarisation jumps when axons are myelinated. Ok myelin is an insulator so in that section no current passes through. But how does that make the current jump, when current reached myelin wouldn't it be inhibited, why does it still travel. Also what do they mean by developing current sinks at nodes of ranvier. Thanks :smile:

the current does not pass through the myelin. The myelin is wrapped around the neuron (like a plastic insulator is wrapped around copper wires). This prevents charge leakage, since (as you say) current can't pass through an insulator.

The mechanism is called "saltatory conduction" for your research pleasure.
 
Myelin acts as an insulator between nodes creating a defacto capacitor like linkage, the impedance of capacitors is high to DC and low to AC while nerve condution is low frequency compared to most communications it is still high enough to transmit like AC.

Think of the myelin sheath and nodes as being a series of capacitors not only faster but more efficient as only the membrane in the node needs to repolarize after each transmission
 

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