Resting membrane potential and some neurophysio questions?

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SUMMARY

The discussion centers on the physiological concepts of resting membrane potential, nerve impulse conduction, and muscle twitch latency. Key points include the importance of increased permeability of the cell membrane to K+ over Na+ for maintaining resting membrane potential, and the role of the neuromuscular junction in the latent period of muscle twitch. Participants clarify that orthodromic conduction occurs in myelinated nerves and discuss factors affecting nerve conduction velocity, such as compression and fatigue. The conversation emphasizes the significance of neurotransmitters like adrenaline in modulating excitability at the neuromuscular junction.

PREREQUISITES
  • Understanding of resting membrane potential and ion permeability
  • Knowledge of orthodromic and antidromic conduction in neurons
  • Familiarity with neuromuscular junction physiology
  • Concept of nerve conduction velocity and its influencing factors
NEXT STEPS
  • Research the Nernst equation for calculating equilibrium potential of K+ and Na+
  • Study the effects of neurotransmitters on neuromuscular junction excitability
  • Explore the relationship between stimulus strength and muscle twitch latency
  • Investigate the impact of mechanical deformation on membrane electrical properties
USEFUL FOR

Neuroscience students, physiologists, and anyone interested in neurophysiology and muscle function will benefit from this discussion.

sameeralord
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Hello everyone,

These are true,false questions. I'm on holiday so can't get help yet and this is not homework.

1.Increased permeability of the cell membraneto K+ than Na+ is important for maintaining resting membrane potential of cell?

Ok I know this is true but I don't understand this. In a normal cell I know this is how it is, but if there was a cell that was more permeable for Na+ why won't it be able to maintain a resting membrane potential of a different value.

2. Orthodontic conduction of a nerve impulse dies out at first synapse?
I know orthodonic conduction is going from stroma to axon, but I don't understand the question.
Myelinated nerves only carry out othrodromic conduction?
I don't understand why?

3. Latent period obeserved in a simple muscle twitch obtained from a nerve muscle preparation.

*Is mostly due to delay at the neuromuscular junction
I know latent period is the time taken for stimulation to migrate to the recording electrode. So false I think.
*Becomes shorter when the strength of stimulus is increased
Due to all or none principle, which has no emphasis on strength of stimulus. I think this has no effect. So false I think.
*Is shorter if adrenalin is added to the solution
I don't know this. Does neurotransmitter decrease latent period
*Can be varied by altering the point of stimulation along the length of the nerve.
This is true I think. This decreases the distance between stimulating and recording electrodes.
*Increased with repeated and prolonged stimulation of nerve.
This is false due to habituation I think.

4. Nerve condcution velocity
* Is reduced when nerve is compressed
* Is reduced in fibres supplying fatigued muscles.

I don't know the answers for these. First one obviously looks true, but what is the reasoning. Second one I think is false.

Thanks a lot in advance :smile:
 
Last edited:
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1- what is the equilibrum potential of K and Na, respectively? What happens to the membrane potential when the permeability for a ion increase?

2- I don't understand the question

3-
*ok
*ok
*more adrenalins means more excitability of the neuromuscular jonction. Does this change the latent period?
*ok
*that false, but not because of habituation. What is the cellular locus of most plasticity? Does a repeated stimulation affect the all or none principle?

4-ok. Can mechanical deformations affect the electrical properties of a membrane?
 

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