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I've been reading a bunch of articles in this month's Scientific American on Alzheimer's and ran across this article in a web feed that I subscribe to. The SA articles that I've read so far have touched on issues with the blood-brain barrier but this appears to be a novel approach to the problem - fix the exit ramp and the brain clears out the plaques.
https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours
The original paper:
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
https://www.sciencealert.com/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours
The original paper:
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport