Nuclear fusion results in a loss of mass, which is converted into energy, primarily due to the binding energy of the resulting atom. The mass of a bound system, such as a helium atom formed from two protons and two neutrons, is less than the sum of its individual constituents because of this binding energy. This phenomenon is not unique to atomic nuclei; it also applies to larger systems, like the Earth-Moon system, which has a lower measured mass than the sum of its separate masses when not bound. The energy released during fusion comes from the increased binding energy in the fused state, while fission involves energy changes related to the Coulomb force. Understanding the relationship between mass and energy is crucial, as mass can be viewed as a measure of energy in a system's rest frame.