To address the issue in the title of this thread... orthogonality in Minkowski spacetime
Based on
https://www.physicsforums.com/threads/angles-in-minkowski-space.991133/post-6364132
and
https://physics.stackexchange.com/a/600504/148184
Physically, given the 4-velocity of an inertial observer,
that observer's sense of space is a "[hyper]plane of simultaneity",
which is
geometrically, determined by the tangent [hyperplane] to the "unit hyperboloid" at the tip of the 4-velocity.
This defines "orthogonality" or "perpendicularity" to the 4-velocity vector.
More details (based on my stackexchange answer):
The "lines of simultaneity (i.e, equal-assignments-of-t)" are determined by the tangents to the "circles" [in the respective geometries], which is a hyperbola in Special Relativity (arising from the invariance of the speed of light).
The "circle" is determined by the set of all observer "tick-1"s.
The "circle" defines perpendicularity: the tangent is perpendicular to the radius...
"the Space[line] is Perpendicular to the Time[line] (worldline)", as Minkowski described in his "Space and Time".
From Minkowski's "Space and Time"...
We decompose any vector, such as that from O to x, y, z, t into four components x, y, z, t. If the directions of two vectors are, respectively, that of a radius vector OR from O to one of the surfaces ##\mp F=1##, and that of a tangent RS at the point R on the same surface, the vectors are called normal to each other. Accordingly,
$$c^2tt_1 − xx_1 − yy_1 − zz_1 = 0$$
is the condition for the vectors with components x, y, z, t and ##x_1##, ##y_1##, ##z_1##, ##t_1## to be normal to each other.
See this definition used in
https://www.desmos.com/calculator/r4eij6f9vw (robphy's spacetime diagrammer v.3)
https://www.desmos.com/calculator/kv8szi3ic8 (robphy's spacetime diagrammer for relativity v.8d-2020)
First, vary the ##v_1## and ##v_2## sliders to get a feel for "tangency".
For the E-slider = +1, we have Minkowski spacetime
(on your way to E= -1 for Euclidean space, note the E=0 case is the Galilean spacetime)
Here is E = +1 (Minkowski)
E= -1 (Euclidean)
Further details:
https://physics.stackexchange.com/a/638018/148184