I was thinking about painkillers recently after recovering from some major dentistry. In particular, I was wondering if there were any painkillers that do not stress the liver. I imagine the answer is no, as just about any foreign substance will be broken down there -- but I thought it was worth asking about. Aspirin (acetylsalicylic acid), ibuprofen, naproxin, and especially acetaminophen (paracetamol) are hard on the liver, as I understand. I'm not sure, but I imagine Vicodin is as well -- or rather, the small amount of hydrocodone in it is; the acetaminophen certainly is. (My dentist prescribed it for the pain, though this time I didn't feel the need to fill the prescription. I kind of wish I did, in retrospect; the first night the pain didn't let me sleep.) And while I'm thinking of it, what can be combined? Clearly aspirin and acetaminophen can be combined, as they're often sold together; clearly Tylenol can't be taken with Vicodin since that's an acetaminophen overdose. I'd guess that Vicodin could be combined with aspirin or another NSAID, but that two NSAIDs should not be used together -- no Aleve with aspirin -- but I don't know.