I have a Master's degree in Physics and am planning to switch over to Biophysics and wish to know a but about the field in general in terms of the following aspects. I've had a few internships on Biophysics in the past and have loved working in this field. However, I have absolutely no experimental experience. I also do not have a solid foundation of biological concepts in terms of formal courses in my university (I only did one introductory course on Biotechnology). Would this affect me as a researcher in this field in the future? I love solving problems in Mathematics and Physics and developing an understanding of physical concepts through a bottom-up approach. On the contrary, with my experience in Biophysics, I have a feeling that biophysics has a top-down approach based on observations on experience and different than physics in that aspect (please correct me if I'm wrong). Although I do like learning about biological systems, I feel that this difference of approach would be an obstacle for me in doing research as a biophysicist and may eventually lead me into disliking the subject. Is this a valid assumption? Are there any discoveries in Biophysics that have been made based on theoretical research and later confirmed through experiments?