Positive charge of NAD+ molecule

In summary, the positive charge of the NAD+ molecule is located on the nitrogen in the nicotinamide group because it has 4 bonds attached to it and a free lone pair of electrons. Protonation by H+ results in a neutral molecule becoming an anion, and for determining formal charge, all electrons in lone pairs and inner shells are considered to belong to the atom. Thus, the nitrogen in this system has a formal charge of +1.
  • #1
tickle_monste
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1
Why is the positive charge of the NAD+ molecule located on the nitrogen in the nicotinamide group? This nitrogen has 4 bonds attached to it, but nitrogen only has 3 holes in its valence shell, so wouldn't this make a negative charge on this nitrogen?
 
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  • #2
tickle_monste said:
Why is the positive charge of the NAD+ molecule located on the nitrogen in the nicotinamide group? This nitrogen has 4 bonds attached to it, but nitrogen only has 3 holes in its valence shell, so wouldn't this make a negative charge on this nitrogen?

Draw the lewis dot structure for the nitrogen in this system and you will see a free lone pair of electrons before protonation by H+. Is it true that when you protonate a neutral molecule with H+ you are left with an anion?
 
  • #3
In general, for determining the formal charge on an atom, we consider all of the electrons in lone pairs and inner shells as belonging to that atom as well ashalf of the electrons in chemical bonds as belonging to that atom. Therefore, the nitrogen has 4 bonds attached to it (giving 4 electrons) plus two inner shell electrons, giving a total of 6 electrons to nitrogen's 7 protons.
 

What is the positive charge of NAD+ molecule?

The positive charge of NAD+ molecule is +1.

How does NAD+ molecule acquire its positive charge?

NAD+ molecule acquires its positive charge by accepting a hydrogen atom and two electrons during redox reactions.

Why is the positive charge of NAD+ molecule significant in cellular respiration?

The positive charge of NAD+ molecule is significant in cellular respiration because it allows it to act as an electron carrier, aiding in the production of ATP.

Can the positive charge of NAD+ molecule change?

Yes, the positive charge of NAD+ molecule can change depending on whether it is in its oxidized form (NAD+) or reduced form (NADH).

What is the role of the positive charge of NAD+ molecule in metabolism?

The positive charge of NAD+ molecule plays a crucial role in metabolism as it helps in the transfer of electrons during cellular respiration and other metabolic pathways, ultimately leading to the production of energy for the cell.

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