Possible to find amount of a substance in tissue sample?

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Quantifying the amount of a polymer hydrogel, specifically poly[N-(2-hydroxypropyl) methacrylamide], in tissue samples is feasible using analytical chemistry methods. Techniques such as spectroscopy or chromatography can be employed to measure the concentration of the substance accurately. For comprehensive methodologies and specific protocols, consulting relevant scientific literature is essential.

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If one has a tissue sample that contains a known substance (specifically a polymer hydrogel of poly[N-(2-hydroxypropyl) methacrylamide), is there a way to quantify the amount of that substance in the sample, or a way to compare the relative amount of the substance in multiple tissue samples?
 
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Whole analytical chemistry deals with methods designed to solve this type of the question. I suppose the answer is yes - but for details you will need to consult literature.
 

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