Volume and temperature rise in tissue

Click For Summary
SUMMARY

The discussion centers on the relationship between the volume of biological tissue samples and their temperature rise when irradiated by a laser. It is established that smaller samples reach higher temperatures due to their lower heat capacity, which is an extensive property that increases with mass. The key equations referenced include the heat conduction equation and the relationship between deposited energy, mass, heat capacity, and temperature rise. The participants emphasize the need to consider the laser penetration depth and the heat diffusion process to derive an explicit formula relating sample volume to temperature rise.

PREREQUISITES
  • Understanding of thermodynamics and heat transfer principles
  • Familiarity with the heat conduction equation
  • Knowledge of heat capacity and specific heat capacity
  • Experience with laser-material interactions, particularly in biological tissues
NEXT STEPS
  • Research the derivation of the heat conduction equation in semi-infinite media
  • Study the relationship between heat capacity and sample mass in thermodynamics
  • Explore numerical methods for solving transient heat conduction problems
  • Examine the effects of laser penetration depth on temperature distribution in tissues
USEFUL FOR

Researchers in biomedical engineering, physicists studying laser-tissue interactions, and professionals involved in thermal analysis of biological materials will benefit from this discussion.

  • #31
Thank you very much for your input.

Chestermiller said:
The equation in post #22 is just what this equation predicts at z = 0.

I see. I guess we used z=0 because at short times the heat hasn't really traveled much into the stem.

If water is substituted for tissue (a zero-order approximation), do you know for what sort of timescales each of the equations in post #25 are valid?

Chestermiller said:
No. It is the spatial part of the asymptotic temperature variation at long times.

So ##\theta_{\infty}(t,z)## is valid for long times t, and also for long z (far removed from heat source ##q##)?

Chestermiller said:
q is the integral of Q over the length of the stem. That is ##q=\int_0^L{Qdz}## (Don't forget to include the attenuation of I)

So, when we write ##Q=I \alpha## doesn't that already account for the attenuation? Isn't this what you mean by the attenuation of I?

The attenuation coefficient of a sample is related to the absorption coefficient through:

$$\gamma=\underbrace{\alpha}_{\text{absorption coefficient}}+\underbrace{\beta}_{\text{scattering coefficient}}$$
 
Science news on Phys.org
  • #32
roam said:
Thank you very much for your input.

I see. I guess we used z=0 because at short times the heat hasn't really traveled much into the stem.
Yes.
If water is substituted for tissue (a zero-order approximation), do you know for what sort of timescales each of the equations in post #25 are valid?
It depends on the specific physical properties. As a rule of thumb, the short time solution is good approximation for ##\xi<1## and the long time solution is good for ##\xi>1##.

So ##\theta_{\infty}(t,z)## is valid for long times t, and also for long z (far removed from heat source ##q##)?
As I said, it's good for values of ##\xi>1##. For a finite sample like this, it applies to all values of z at long times.

So, when we write ##Q=I \alpha## doesn't that already account for the attenuation? Isn't this what you mean by the attenuation of I?

The attenuation coefficient of a sample is related to the absorption coefficient through:

$$\gamma=\underbrace{\alpha}_{\text{absorption coefficient}}+\underbrace{\beta}_{\text{scattering coefficient}}$$
I was neglecting scattering. In that case, $$\frac{dI}{dz}=-\alpha I$$and $$q=I(0)e^{-\alpha z}$$So, $$q=I_0\int_0^{\infty}{\alpha e^{-\alpha z}dz}=I_0$$This assumes that all the attenuation takes place a short distance from the interface, and neglects the finite length of the stem.
 
  • Like
Likes   Reactions: roam
  • #33
Hi Chestermiller,

I had just a few more questions.

I was looking at another textbook, and they define the Fourier Number differently from your post #25. It is instead given as:

$$\xi=\frac{\alpha t}{l_c^{2}},$$

where ##l_c## is the "characteristic length" given by:

$$l_{c}=\frac{\text{Volume}}{\text{Surface area}}.$$

For a plate of thickness ##L##, we have ##l_c \simeq L/2##.

Do you think this is applicable to my situation?

Chestermiller said:
I was neglecting scattering. In that case, $$\frac{dI}{dz}=-\alpha I$$and $$q=I(0)e^{-\alpha z}$$So, $$q=I_0\int_0^{\infty}{\alpha e^{-\alpha z}dz}=I_0$$This assumes that all the attenuation takes place a short distance from the interface, and neglects the finite length of the stem.

Yes. And according to the reference, the scattering coefficient term will not contribute to the heating of the tissue. But is the minus sign there a typo? In the paper, they give this as: ##Q=\partial I/\partial z = \alpha I##.

Chestermiller said:
It depends on the specific physical properties. As a rule of thumb, the short time solution is good approximation for ##\xi<1## and the long time solution is good for ##\xi>1##.

I see. For some reason, my temperature curves always look like the short-time asymptote — even when the plant is a seedling (##L \approx 1 \ cm##, so ##\xi>1##). Could this be because we neglected the width of the plant?

Chestermiller said:
No. It is the actual temperature.

To make sure I've understood the notations correctly:

##\theta\left(t,z\right)=T(t,z)##
##\theta_{\infty}(t,z)=\Delta T(t,z)\ \text{(none-dimensionless)}##
##\theta^{*}(t)=\Delta T(t)\ \text{(dimensionless)}##

Is that right?

Thank you very much for the help.
 
  • #34
roam said:
Hi Chestermiller,

I had just a few more questions.

I was looking at another textbook, and they define the Fourier Number differently from your post #25. It is instead given as:

$$\xi=\frac{\alpha t}{l_c^{2}},$$

where ##l_c## is the "characteristic length" given by:

$$l_{c}=\frac{\text{Volume}}{\text{Surface area}}.$$

For a plate of thickness ##L##, we have ##l_c \simeq L/2##.

Do you think this is applicable to my situation?
No. The selection of the appropriate length to use depends on the specific physical situation. This is at the discretion of the analyst. In your problem, it is most appropriate to use the length of the sample.
Yes. And according to the reference, the scattering coefficient term will not contribute to the heating of the tissue. But is the minus sign there a typo? In the paper, they give this as: ##Q=\partial I/\partial z = \alpha I##.
This depends on which direction you choose for z. If z is measured in the opposite direction of the photon flow, then the positive sign is appropriate. If z is measured in the same direction as the photon flow, then the negative sign is appropriate.
I see. For some reason, my temperature curves always look like the short-time asymptote — even when the plant is a seedling (##L \approx 1 \ cm##, so ##\xi>1##). Could this be because we neglected the width of the plant?
I think it's more that you have neglected the effect of water vaporization. I would try some experiments where I reduced the intensity of the laser so that the temperature did not rise so much and see how the results compare.
To make sure I've understood the notations correctly:

##\theta\left(t,z\right)=T(t,z)##
##\theta_{\infty}(t,z)=\Delta T(t,z)\ \text{(none-dimensionless)}##
##\theta^{*}(t)=\Delta T(t)\ \text{(dimensionless)}##

Is that right?
Yes.
 
  • Like
Likes   Reactions: roam
  • #35
I also need a little help to walk me through the calculation of ##q## in your post #32.

The energy absorption in a differential distance ##dz## is:

$$dI=-\alpha I dz,$$

so using your convention for measuring z:

$$Q=\partial I/\partial z=-\alpha I.$$

To find the heat flux ##q## we will integrate this between the limits x=0 and x=L:

$$q=\int_{0}^{L}Q\ dz=-\alpha \int_{0}^{L} I\ dz=-\alpha I_{0} \int_{0}^{L}e^{-\alpha z}\ dz,$$

$$q=I_{0}\left[e^{-\alpha L}-1\right],$$

which for ##L\to\infty## reduces to ##-I_{0}## and not ##I_{0}## that you obtained in your post. Why does this negative sign mean?
 
  • #36
roam said:
I also need a little help to walk me through the calculation of ##q## in your post #32.

The energy absorption in a differential distance ##dz## is:

$$dI=-\alpha I dz,$$

so using your convention for measuring z:

$$Q=\partial I/\partial z=-\alpha I.$$
This equation should read $$Q=-\partial I/\partial z=\alpha I$$
 
  • Like
Likes   Reactions: roam

Similar threads

  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 1 ·
Replies
1
Views
2K
  • · Replies 1 ·
Replies
1
Views
2K
  • · Replies 3 ·
Replies
3
Views
1K
  • · Replies 1 ·
Replies
1
Views
3K
  • · Replies 4 ·
Replies
4
Views
2K
  • · Replies 2 ·
Replies
2
Views
2K
  • · Replies 27 ·
Replies
27
Views
5K
  • · Replies 19 ·
Replies
19
Views
2K
  • · Replies 2 ·
Replies
2
Views
2K