Possible to have severe 2021 flu season because of Covid?

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Discussion Overview

The discussion revolves around the potential impact of COVID-19 on the upcoming 2021 flu season, particularly regarding the effectiveness of flu vaccines and the possibility of a severe flu season. Participants explore various factors, including the effects of pandemic measures on flu virus diversity and the implications for vaccine development.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • One participant questions whether the mild flu season due to COVID-19 will hinder the development of an effective vaccine for the 2021 flu season, expressing concern about a potentially deadly flu season.
  • Another participant suggests that the case fatality rate of seasonal influenza is low, indicating that even with reduced cases, there would still be sufficient specimens for vaccine development.
  • Some participants propose that the lifting of COVID-19 preventive measures could lead to an unpredictable resurgence of flu cases, but one argues that a deadly outcome is unlikely.
  • A participant notes that COVID-19 suppression measures have led to a reduction in flu virus diversity, which may simplify the vaccine formulation process.
  • There is speculation about the potential unforeseen effects of mRNA vaccines on flu symptoms, with one participant suggesting that this could lead to more severe flu cases.
  • Another participant challenges the notion that mRNA vaccines could predispose individuals to severe flu symptoms, asking for evidence to support this claim.

Areas of Agreement / Disagreement

Participants express a range of views on the implications of COVID-19 for the flu season, with no consensus on whether a severe flu season is likely or whether vaccine development will be adversely affected. Multiple competing perspectives remain throughout the discussion.

Contextual Notes

Participants acknowledge various uncertainties, including the long-term effects of pandemic measures on flu virus dynamics and the potential impact of mRNA vaccines on flu severity. The discussion reflects a lack of definitive answers regarding these complex interactions.

aheight
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TL;DR
Will the limited availability of influenza cases due to covid hamper our ability to develop an effective flu vaccine for 2021?
Here's a CDC link summarizing how a influenza vaccine is developed: Selecting viruses for flu vaccine However, as you know, we've had a record mild flu season because of covid. I'm wondering if this will adversely affect our ability to create an effective vaccine for the 2021 flu season due to the relative lack of specimens? Are we headed for a deadly flu season because of covid? Should we be concerned? If it becomes deadly, I suspect we wouldn't have time to recover (develop a new vaccine). I contacted the CDC about this. Curious if they'll reply. Was wondering what you guys think.
 
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I don't know the answer but it sure is an interesting question
 
First, there is a simple solution - stay locked down forever. If it saves just one life...

Second, seasonal influenza has a case fatality rate of 0.1% and 10's of thousands of deaths per year in the US. That means 10's of millions of people catch it. Even if 99% of the cases that would have happened last year did not, that's 100's of thousands. Plenty of specimens.
 
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aheight said:
Are we headed for a deadly flu season because of covid?
I don't think that just one missed season will cause much problems but indeed, a few years of preventive measures suddenly lifted would likely mean a strong and unpredictable re-start.

But 'deadly'? No.
 
A pandemic upside: The flu virus became less diverse, simplifying the task of making flu shots
With Covid suppression measures like mask wearing, school closures, and travel restrictions driving flu transmission rates to historically low levels around the world, it appears that one of the H3N2 clades may have disappeared — gone extinct. The same phenomenon may also have occurred with one of the two lineages of influenza B viruses, known as B/Yamagata.

Neither has been spotted in over a year. In fact, March of 2020 was the last time viral sequences from B/Yamagata or the H3N2 clade known as 3c3.A were uploaded into the international databases used to monitor flu virus evolution, Trevor Bedford, a computational biologist at the Fred Hutchinson Cancer Research Center in Seattle, told STAT.

If the global pool of flu viruses has truly shrunk to this degree, it would be a welcome outcome, flu experts say, making the twice-a-year selection of viruses to be included in flu vaccines for the Northern and Southern hemispheres much easier work.
https://www.statnews.com/2021/06/02...diverse-simplifying-task-of-making-flu-shots/
 
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Or perhaps unforeseen effects of the novel mRNA vaccine will predispose people to experiencing more severe flu symptoms? I imagine attributing a deadly flu season to a lack of adequately formulated flu vaccines is a better explanation.
 
EHope said:
Or perhaps unforeseen effects of the novel mRNA vaccine will predispose people to experiencing more severe flu symptoms? I imagine attributing a deadly flu season to a lack of adequately formulated flu vaccines is a better explanation.
Do you have any reason to think that this would be the case? I am not aware of anything that would suggest that a vaccine could predispose people to more severe flu symptoms.
 
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