To prove a function is invertible using calculus, it is essential to establish that the function is injective, meaning that if f(a) = f(b), then a must equal b. This injectivity condition ensures that each output corresponds to a unique input, allowing for a well-defined inverse function. A function is injective if it does not have any local maxima or minima, which can be determined by analyzing its derivative; if the derivative does not change sign, the function is monotonic and thus injective. For example, f(x) = x² is not injective over the reals, while f(x) = 2x + 1 is injective. Understanding the relationship between a function's injectivity and its inverse's domain and range is crucial for establishing invertibility.