Quantum Theory & Null Hypothesis: Impact & Obsoleteness

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I try to rephrase:

How can we choose "safe" critical value or significance level in a framework of QT when applying the null hypothesis?

Does this make any sense?
 
In most sciences about 2 standard deviations (95% confidence) is traditional. Modern physics, however, tends to use much higher levels, like 5 standard deviations (99.9999% confidence).