Question about Cells and Cell Channels

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SUMMARY

The discussion centers on designing cells with a specific number of open channels, emphasizing that the standard deviation of these channels must not exceed one percent of the expected number. The forum participants seek to derive formulas for the minimum number of channels (M) and the minimum radius (a) of a spherical cell based on given parameters p, q, and density D. The minimum radius calculated for a fixed probability p of 0.05 and a density D of 200 channels per μm² is confirmed to be 8.69 μm. Participants are encouraged to explore the Poisson distribution for further insights.

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  • Understanding of Poisson distribution
  • Knowledge of cellular biology and membrane structure
  • Familiarity with mathematical modeling in biological contexts
  • Basic principles of density calculations in three-dimensional geometry
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  • Research the application of Poisson distribution in biological systems
  • Explore mathematical modeling techniques for cell design
  • Study the relationship between cell size and channel density
  • Investigate advanced topics in membrane biology and channel functionality
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Biologists, bioengineers, and researchers involved in cellular design and membrane studies will benefit from this discussion, particularly those focusing on channel density and its implications for cell functionality.

atlbraves49
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Imagine that it is possible to design cells of varying size. A cell is to be
designed with a membrane that has a stable number of open channels. To
this end, the number of channels must meet the following condition: the
standard deviation of the number of open channels shall be no more than
one percent of the expected number of open channels.

(a) In terms of p and q, give the formula for M, where M is the
minimum number of channels that the cell must have.

(b) Assuming a spherical cell, give a formula for a, where a is the
minimum radius that the cell must have to hold the required number
of channels, at density D. (answer must be in terms of q, D and p,
and constants only).

(c) What is the minimum radius, a, that the cell must have to hold the
required number of channels if the probability p is fixed at 0.05 and
D is 200 channels per μm2?



This is just review so if anyone could help me figure out this problem i would appreciate it. I know the answer to c is 8.69um, but unsure how to reach that result.
 
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Read up on the Poisson distribution.
 
thats not mentioned in our chapter at all (or in class) , could it be something else?

some help with solving the problem would be helpful.
 

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