Reduction of moisture content form propylene glycol

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SUMMARY

Applying a vacuum of approximately 15000 mTorr for 24 hours effectively reduces moisture content in polyethylene glycol (PEG) and propylene glycol (PG). This method is particularly useful for formulations where moisture levels of 4-6% negatively impact product stability. The discussion references a study on peroxide removal in polyethylene glycols, highlighting the importance of vacuum drying in maintaining the integrity of biotech and pharmaceutical formulations.

PREREQUISITES
  • Understanding of vacuum drying techniques
  • Familiarity with polyethylene glycol (PEG) and propylene glycol (PG) properties
  • Knowledge of moisture content effects on product stability
  • Basic principles of pharmaceutical formulation
NEXT STEPS
  • Research vacuum drying methods for PEG and PG
  • Study the effects of moisture content on pharmaceutical formulations
  • Explore the implications of peroxide removal in PEG
  • Investigate advanced vacuum technologies for moisture reduction
USEFUL FOR

Formulators, chemists, and pharmaceutical professionals involved in product development and stability testing of polyethylene glycol and propylene glycol formulations.

Balaji
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Is it possible to reduce moisture content in Polyethylene glycol or propylene glycol by applying vacuum to around 15000 mTorr for 24 hours. If anyone has any idea please let me know
 
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Thank U very much Mr.Douq Huffman. I'm working on a process where 4-6% of moisture is introduced through the ingredients what we add into PEG and propylene glycol but this % of water is detrimental to the product. So by applyin vacuum can I reduce the moisture in PEG and PG solutions
 

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