Define "detrimental" and "grade". Assuming you mean octane rating: The purpose of higher octane gas is to eliminate pre-ignition/knocking at higher compression ratios. So if your engine doesn't have a high compression ratio, there's no benefit to higher octane gas/detriment to lower octane.
Engine knocking can damage an engine. So if you do use low octane gas on a high compression ratio older car, yes, it can be detrimental. But newer engines with computer-controlled timing and combustion have knock sensors that can make adjustments in ignition to avoid the knocking and reduce the potential for damage:
https://www.thedrive.com/cars-101/35148/what-is-a-knock-sensor
The bottom-line is: Read the car's manual (or look on/in the gas cap) to determine what kind of gas to use.
The below-the-bottom-line is: My car (Kia Stinger, 2.0T) has vague guidance that has been altered between model years to be even more vague. Higher octane gas is recommended but evidently not required. There's spirited debate online regarding what this means, with the consensus seeming to be that if you use lower octane gas against the recommendation, the likely result is going to be slightly lower fuel economy but no harm.