The Evolution of Alcohol Tolerance: A Genetic Response to Human Consumption?

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Discussion Overview

The discussion centers on the genetic evolution of alcohol tolerance in humans, exploring the potential selection pressures that have influenced this trait across different populations. Participants examine historical contexts, the role of alcohol in society, and the implications of varying alcohol consumption practices.

Discussion Character

  • Exploratory
  • Debate/contested
  • Historical

Main Points Raised

  • Some participants propose that alcohol tolerance may have undergone significant genetic selection due to varying consumption patterns across different populations.
  • There is speculation about whether the craving for alcohol existed before its abundance in society or if it developed as a beneficial trait after the invention of alcoholic beverages.
  • One participant suggests that individuals less affected by alcohol may have had more offspring, potentially leading to a population more vulnerable to alcohol compared to sober groups.
  • Another participant notes that light alcohol (around 5%) might hydrate individuals and be less toxic, raising questions about its historical consumption.
  • Concerns are raised about why alcohol tolerance appears to be strongest in Europe and the Mediterranean, with suggestions of climate suitability and trade relationships as contributing factors.
  • Historical references are made to the consumption of alcohol in Medieval Europe as a safer alternative to contaminated water, prompting questions about its impact on genetic selection for alcohol tolerance.
  • One participant mentions the strong selection pressure associated with mortality from unsafe drinking water and references the enzyme alcohol dehydrogenase as a point of interest.

Areas of Agreement / Disagreement

Participants express multiple competing views regarding the origins and implications of alcohol tolerance, with no consensus reached on the specific factors that contributed to its evolution.

Contextual Notes

Limitations include the lack of definitive evidence regarding the historical prevalence of alcohol consumption versus water safety, as well as the complexity of genetic selection processes in relation to alcohol tolerance.

Balloono
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As different individuals and races are very different comparing this trait, alcohol tolerance has/is probably under heavy genetic selection. As there isn't much alcohol outside human society, i wonder whether people craved alcohol by accident already before it became abundant or did that trait also become more prominent after alcoholic inventions. If the first one is true then possibly people less affected by alcohol gave more children but the whole group became vulnerable compared to sober human populations. If the latter is true then it was beneficial being able to consume alcohol and doing a lot of it. As i understand light alcohol (5%) does in fact hydrate you? and is less prone to becoming poisonous in other ways? Also why alcohol tolerance became strongest in Europe, Mediterranean? More suitable climate and more extensive trade relationships?
 
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Balloono said:
Also why alcohol tolerance became strongest in Europe, Mediterranean? More suitable climate and more extensive trade relationships?
Because everybody who drank the water instead of beer died of dysentry/cholera/typhoid/the dreaded lurg

If tea had been around in europe then people might have drunk tea instead like most east-asians
 
Balloono said:
As different individuals and races are very different comparing this trait, alcohol tolerance has/is probably under heavy genetic selection. As there isn't much alcohol outside human society, i wonder whether people craved alcohol by accident already before it became abundant or did that trait also become more prominent after alcoholic inventions. If the first one is true then possibly people less affected by alcohol gave more children but the whole group became vulnerable compared to sober human populations. If the latter is true then it was beneficial being able to consume alcohol and doing a lot of it. As i understand light alcohol (5%) does in fact hydrate you? and is less prone to becoming poisonous in other ways? Also why alcohol tolerance became strongest in Europe, Mediterranean? More suitable climate and more extensive trade relationships?

If I remember correctly in Medieval Europe alcohol was consumed quite frequently as it was safer to drink than the water in most places, whether this would be large enough effect to cause a selection pressure for Europeans to have a higher alcohol tolerance or not I don't know, I'll have a look for some papers on it. Obviously this tolerance would then be passed onto Americans, Australians etc. who were descended from European colonists.
 
Vagn said:
If I remember correctly in Medieval Europe alcohol was consumed quite frequently as it was safer to drink than the water in most places,
It was the only safe drink in europe from the Romans to the start of 20C

whether this would be large enough effect to cause a selection pressure for Europeans to have a higher alcohol tolerance or not I don't know,
Dying has quite a strong selection pressure - lookup Alcohol dehydrogenase
 

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