The meaning of protein phosphorylation to bioscience?

[littledog]

Many researchers have mentioned in their researches that protein phosphorylation take a decisive position to regulate various physiological activity, from prokaryote to eukaryote.
So did anyone has taken the research on control the protein phosphorylation in wildtype microorganisms with aritificial induce?

 

[Mr Green T]

With hundreds of thousands of protein phosphorylation sites and the current limitation of production in vitro the approaches to take are just beginning to emerge.

Synthetic approaches to protein phosphorylation

 

[littledog]

With hundreds of thousands of protein phosphorylation sites and the current limitation of production in vitro the approaches to take are just beginning to emerge.

Synthetic approaches to protein phosphorylation

Is there any research about this?

 

[Mr Green T]

Is there any research about this?

Replied via conversation feature.

 

[docnet]

So did anyone has taken the research on control the protein phosphorylation in wildtype microorganisms with aritificial induce?

Many signaling pathways that deal with a wide range of biological processes such as cell growth, metabolism, and differentiation involve proteins which are phosphorylated. The tyrosine kinase receptor, for example, is a receptor whose intracellular domain is phosphorylated upon substrate binding. Artificially creating a fusion gene naturally present in the "Philadelphia chromosome" which codes for the breakpoint cluster region acute lymphoblastic leukemia protein produces a TKR with whose intracellular domain is constitutively phosphorylated. - summarized from multiple chapters of The Biology of Cancer

 

[J Boogie]

The fact is phosphates are ubiquitous in organisms, for example, the backbone of DNA is phosphorylated, the major energetic molecule is phosphorylated (ATP). In short, if it can be, it will be, phosphorylated. It is an essential organic chemistry of life. Essentially all phosphorylation means is the addition of a phosphate functional group (PO4+) to a molecule.