Titrating ASA Tablets: NaHO and Ethanol

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SUMMARY

The discussion focuses on the titration of acetylsalicylic acid (ASA) tablets using sodium hydroxide (NaOH) and ethanol. Participants confirm that hydrolyzing ASA with excess NaOH converts it to salicylate, followed by pH adjustment and the addition of iron to form a purple complex for measurement. The use of a Spec 20 spectrophotometer is highlighted as a key tool for analyzing the intensity of the Fe complex. Accurate dissolution of the tablet is essential for reliable results.

PREREQUISITES
  • Understanding of titration techniques
  • Knowledge of acetylsalicylic acid (ASA) chemistry
  • Familiarity with sodium hydroxide (NaOH) and its properties
  • Experience with spectrophotometry, specifically using a Spec 20
NEXT STEPS
  • Research the procedure for hydrolyzing acetylsalicylic acid with NaOH
  • Learn about the formation of salicylate from ASA and its implications
  • Study the principles of spectrophotometry and how to use a Spec 20
  • Investigate the effects of ethanol on the solubility of ASA in titration
USEFUL FOR

Chemistry students, laboratory technicians, and researchers involved in pharmaceutical analysis or titration methods.

appykid
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How do I find the quantity of active ingredient in a commercial ASA tablet, using titration and NaHO? I think that I'm supposed to use ethanol too.
 
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When I did that test back in the day, we used iron to complex with the stuff and measured the intensity of the Fe complex. You could use NaOH in theory but you will need to get the whole tablet to dissolve to accurately analyze it. Ethanol should work but I'm not sure.

We hydrolyzed the acetylsalicyclic acid with excess NaOH to salicylate and then adjusted the pH to neutral and added the Fe to generate the purple complex. I remember using a Spec 20 for the analysis.
 

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