To perform a regression in Excel for the equation y = C(x^n), the logarithmic transformation is necessary, leading to the model ln(y) = ln(C) + n*ln(x). The discussion highlights that Excel's regression tools have significant limitations, including issues with statistical accuracy and the handling of residuals. Users express skepticism about using Excel for regression analysis due to its flawed algorithms and lack of support for robust statistical methods. The conversation also clarifies that exponential and polynomial regression are distinct, and conflating them can lead to analytical errors. Overall, while Excel is widely accessible, it may not be the best choice for rigorous regression analysis.