What Factors Contribute to Aging and Death in the Human Body?

[EpiGen]

Does anybody know what mechanisms in the human body contribute to the wear and tear that comes with aging, and eventually lead to death? I know that DNA telomers shortening is one. What are some others? Maybe the accumulation of DNA mutations throughout a lifetime? Thanks!

 

[Quantum-lept]

careful choice of parents is extremely important!..gotta get them good genes!(:

plaque in arteries and brain compromises long life.

I guess it comes down to genes and their mutations at birth, assaults by environment, and those shortening telomeres.Depending on which organ or organs begin to fail and the resulting cascade to other systems determines length of life.