The real issue is that we can't be Gods, mainly due to the fact that we can't influence our surroundings beyond the things we do on Earth (and even then, not all of us have that kind of influence). No matter what we do, the existence will still rear it's ugly head: every morning/night the same picture, same sky, clouds, stars, cosmos, you name it. That's something I see no solution for.
In terms of being successful here on Earth, sure, it would be wise to think of everything in positive terms, to follow your dreams and to consider yourself a God for
yourself.
But that is the real subtlety here: if the universe doesn't care, then how is it a worthy life we live? no matter what we do, we are going to die. If a cure is found for Death (if such a thing is possible), then that would only
exacerbate the problem because I would personally be unable to enjoy this daily repetitiveness and how exactly would immortality really be immortality if everyone in possession of arms would be able to kill himself? Sure, no physical death, but what about illnesses and about the aforementioned option? There are too many gaping holes to reach a reasonable conclusion
And then again... even then, the Universe wouldn't care
Someone said here, that because we are sentient being, we are so much more meaningful than the universe is as a whole... there is a modicum of truth in that as well, but only insofar as we're alive.