As they say "It all depends on what you mean by" the theory of everything". It is not logical to think in terms of being able to map and predict every event and all we can expect is incremental steps in the direction. It really is naive to expect that we will wake up one day and 'understand' everything. That's the sort of thing that many religions seems to promise for the faithful, after they die. It's the same sort of hyperbole as immortality; something that we can't actually comprehend but which gets talked about an awful lot.
Technology will always take advantage of theoretical advances when it can. But Economics involves humans as well as technology and that will greatly dilute the impact of a TOE.
The recently publicised advances in robotics and AI suggest that we could be heading for a computer driven system. All the themes the Asimov explored, so many years ago, are getting a airing. If the future computers 'decide' that a TOE is desirable, then they will drive it forward, with or without human approval. (I'm sorry Dave; I can't do that.")