Anhydrous salts are less soluble in water than their hydrous counterparts due to the absence of water molecules that stabilize the ionic lattice structure. In the case of Glauber's salt, the hydrous form contains water of crystallization, which helps break the ionic bonds more effectively when dissolved. The strong ionic interactions in anhydrous salts require more energy to overcome, making them less likely to dissolve in water. Additionally, the presence of water molecules in hydrous salts facilitates solvation, enhancing their solubility. Overall, the structural differences between anhydrous and hydrous salts significantly impact their solubility in water.