Why Are Some mRNA Transcripts Bigger Than Others?

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Variations in the size of mRNA transcripts from the same gene can be attributed to differences in poly(A) tail length and alternative splicing events. Poly(A) tails may vary due to differing degrees of degradation, impacting transcript size. Additionally, alternative splicing allows for the production of multiple mRNA isoforms, leading to transcripts of different lengths. These mechanisms contribute to the diversity of mRNA transcripts in gene expression. Understanding these processes is crucial for comprehending gene regulation and expression dynamics.
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Homework Statement


After isolating the same mRNA transcripts of the same gene, why are some transcripts bigger than others?

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The Attempt at a Solution

 
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Consider what happens to mRNAs after they are initially synthesized.
 
polyA tail?
 
Yes, the poly(A) tails can be of differing length (e.g. some poly(A) tails may have undergone more degradation than others). The mRNAs can also be alternatively spliced resulting in differently sized transcripts.
 

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