Why Are Some mRNA Transcripts Bigger Than Others?

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SUMMARY

The discussion addresses the variability in size among mRNA transcripts of the same gene, highlighting two primary factors: the length of poly(A) tails and alternative splicing. Poly(A) tails can differ in length due to varying degrees of degradation, while alternative splicing allows for the production of multiple transcript variants from a single gene. These mechanisms contribute to the observed differences in mRNA transcript sizes.

PREREQUISITES
  • Understanding of mRNA synthesis and processing
  • Knowledge of polyadenylation and its role in mRNA stability
  • Familiarity with alternative splicing mechanisms
  • Basic molecular biology concepts related to gene expression
NEXT STEPS
  • Research the process of polyadenylation in eukaryotic cells
  • Explore the mechanisms and significance of alternative splicing
  • Investigate the impact of mRNA degradation on transcript stability
  • Learn about the techniques used to analyze mRNA transcript size variations
USEFUL FOR

Molecular biologists, geneticists, and students studying gene expression and RNA biology will benefit from this discussion.

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Homework Statement


After isolating the same mRNA transcripts of the same gene, why are some transcripts bigger than others?

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The Attempt at a Solution

 
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Consider what happens to mRNAs after they are initially synthesized.
 
polyA tail?
 
Yes, the poly(A) tails can be of differing length (e.g. some poly(A) tails may have undergone more degradation than others). The mRNAs can also be alternatively spliced resulting in differently sized transcripts.
 

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