Why Do Up & Down Quarks Have Different Charge?

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Is there a simple explanation for why up & down quarks have different charge?
 
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When "quarks" were invented by Gell-Mann and Zweig, they were simply associated the charges (2/3 elementary charges for the up, -1/3 for the down quark) such that the correct charge pattern for the hadrons resulted. See,

http://en.wikipedia.org/wiki/Eightfold_Way_(physics)

for the SU(3)-constituent-quark model.

Nowadays this charge pattern, together with the 3 colors of the color SU(3) underlying QCD, make the Standard Model consistent in avoiding a chiral anomaly of the weak gauge group ##\mathrm{SU}(2)_{\text{wiso}} \times \mathrm{U}(1)_{\text{Y}}.##
 
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