First, think about systems of simultaneous linear equations and how they analyzed with matrices. Traditionally, we write the system in the form [itex]M\ x = b[/itex] with the left hand side being the product of a matrix multiplied on the right by a column vector (as opposed to a matrix multiplied on the left by a row vector). The product [itex]M\ x[/itex] of a matrix times a column vector can be viewed as a linear combination of the columns of [itex]M[/itex] with coefficients taken from the entries of [itex]x[/itex].
Writing the jth column of [itex]M_{*.j}[/itex]
[itex]M\ x = x_1 M_{*,1} + x_2 M_{*.2} + ... x_n M_{*,n}[/itex]
If we have more or fewer unknowns than equations, the matrix [itex]M[/itex] isn't square, so we can't do an analysis by taking its determinant. When [itex]M[/itex] is a square matrix and its derminant is non-zero, we can find a unique solution for variables [itex]x[/itex]. In particular , we can find a unique solution for the system [itex]M\ x = b[/itex] when [itex]b[/itex] is the column vector of zeroes. The unique solution to [itex]M\ x = 0[/itex] would be [itex]x_j = 0[/itex] for all [itex]j[/itex]..
If the column vectors of [itex]M[/itex] were dependent then solution for [itex]M\ x = 0[/itex] would not be unique. For example if [itex]M_{*,1} = \sum_{j=2}^n a_j M_{*,j}[/itex] with at least one of the [itex]a_j[/itex] nonzero then the values [itex]x_1 = 1[/itex] and [itex]x_j = -a_j[/itex] for [itex]j > 1[/itex] would be a nonzero solution to [itex]M\ x = 0[/itex].
By analogy, the Wronskian [itex]W[/itex] is the derminant of a square matrix of functions [itex]M[/itex] . A column vector of [itex]M[/itex] gives a function and it's successive derivatives. If [itex]W[/itex] is nonzero then [itex]M\ x = 0[/itex] has the unique solution [itex]x= 0[/itex] , so the column vectors of [itex]M[/itex] are independent.
That's just "by analogy". There would be lots of technicalities to consider if we want to prove anything about solutions to a differential equation. At least the analogy reminds us that a given column has entries all relate to the same function ( and a given row has entries that all relate to the same order of differentiation).