Why doesn't decreased insulin secretion during stress cause problems?

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SUMMARY

During stress, specifically in fight-or-flight situations, alpha 2 adrenergic receptors inhibit insulin secretion from pancreatic beta cells, leading to increased blood sugar levels. This mechanism is crucial as epinephrine, a nonselective agonist of adrenergic receptors, stimulates glycogenolysis and glycolysis in muscles, compensating for decreased insulin. Research indicates that muscle tissues can enhance glucose uptake through alternative receptors independent of insulin, ensuring energy production remains efficient during stress.

PREREQUISITES
  • Understanding of alpha 2 adrenergic receptors
  • Knowledge of insulin's role in glucose metabolism
  • Familiarity with epinephrine's mechanism of action
  • Basic concepts of glycogenolysis and glycolysis
NEXT STEPS
  • Research the role of alpha 2 adrenergic receptors in metabolic regulation
  • Study the effects of epinephrine on muscle glucose uptake
  • Explore alternative glucose uptake mechanisms in muscle tissues
  • Investigate the physiological implications of insulin inhibition during stress
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Medical students, physiologists, endocrinologists, and anyone interested in the biochemical responses to stress and metabolic regulation.

tarekatpf
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During fight-or-flight situations, alpha 2 receptors ( which are inhibitory receptors ) of the pancreatic beta cells are stimulated, and as a result there's decreased insulin production. While it benefits the body by producing increased blood sugar level, I don't understand why Insulin doesn't cause some problems. Such as, since insulin increases glucose intake by the muscle tissues ( skeletal muscles are supposed to be used more in flight-or-fight situations ) and increases glycolysis ( which produces energy ), wouldn't decreased insulin release during flight-or-fight situations cause less glucose intake and less glycolysis ( as a result less energy production ) by the muscle tissues? And wouldn't less energy produced by the muscle tissues cause them work less efficiently?
 
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Adrenaline!

Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α1, α2, β1, β2, and β3.[15] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.[20]

http://en.wikipedia.org/wiki/Epinephrine#Mechanism_of_action

Reference [20] (a textbook):

http://books.google.ca/books?id=zFl...s+of+Medical+Physiology&source=gbs_navlinks_s
 
Overall ongoing research also confirms that muscles can increase their glucose uptake
via other receptors or channels independent of INSULIN also.
Adrenaline pumps them up !

reference Ganong medical physiologe 23 edition.
 
Last edited by a moderator:
Manish7 said:
reference Ganong medical physiologe 23 edition.
Please post a link to the specific passage you are referencing in this book. Thank you. The book is copyrighted, so you may only quote the specific passage.
 

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