Why doesn't decreased insulin secretion during stress cause problems?

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Discussion Overview

The discussion centers around the physiological effects of decreased insulin secretion during stress, particularly in fight-or-flight situations. Participants explore the implications of this decrease on glucose uptake and energy production in muscle tissues, as well as the role of adrenaline in these processes.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • One participant questions why decreased insulin during stress does not lead to problems, suggesting that less insulin would result in reduced glucose intake and energy production by muscle tissues.
  • Another participant highlights the role of adrenaline (epinephrine) in counteracting decreased insulin secretion by stimulating glycogenolysis and glycolysis in muscles, which may mitigate the concerns raised.
  • A later reply notes that muscles can increase glucose uptake through mechanisms independent of insulin, emphasizing the importance of adrenaline in this process.
  • One participant requests clarification on a reference to a textbook, seeking specific passages related to the discussion.

Areas of Agreement / Disagreement

Participants express differing views on the implications of decreased insulin during stress, with some emphasizing the compensatory role of adrenaline while others remain concerned about potential inefficiencies in muscle energy production. The discussion does not reach a consensus.

Contextual Notes

Participants reference various mechanisms and sources, but there are unresolved assumptions regarding the extent to which adrenaline compensates for decreased insulin and the specific pathways involved in glucose uptake during stress.

Who May Find This Useful

This discussion may be of interest to those studying physiology, endocrinology, or stress responses, as well as individuals curious about metabolic processes during acute stress situations.

tarekatpf
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During fight-or-flight situations, alpha 2 receptors ( which are inhibitory receptors ) of the pancreatic beta cells are stimulated, and as a result there's decreased insulin production. While it benefits the body by producing increased blood sugar level, I don't understand why Insulin doesn't cause some problems. Such as, since insulin increases glucose intake by the muscle tissues ( skeletal muscles are supposed to be used more in flight-or-fight situations ) and increases glycolysis ( which produces energy ), wouldn't decreased insulin release during flight-or-fight situations cause less glucose intake and less glycolysis ( as a result less energy production ) by the muscle tissues? And wouldn't less energy produced by the muscle tissues cause them work less efficiently?
 
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Adrenaline!

Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α1, α2, β1, β2, and β3.[15] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.[20]

http://en.wikipedia.org/wiki/Epinephrine#Mechanism_of_action

Reference [20] (a textbook):

http://books.google.ca/books?id=zFl...s+of+Medical+Physiology&source=gbs_navlinks_s
 
Overall ongoing research also confirms that muscles can increase their glucose uptake
via other receptors or channels independent of INSULIN also.
Adrenaline pumps them up !

reference Ganong medical physiologe 23 edition.
 
Last edited by a moderator:
Manish7 said:
reference Ganong medical physiologe 23 edition.
Please post a link to the specific passage you are referencing in this book. Thank you. The book is copyrighted, so you may only quote the specific passage.
 

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