Why doesn't decreased insulin secretion during stress cause problems?

  • Thread starter tarekatpf
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  • #1
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During fight-or-flight situations, alpha 2 receptors ( which are inhibitory receptors ) of the pancreatic beta cells are stimulated, and as a result there's decreased insulin production. While it benefits the body by producing increased blood sugar level, I don't understand why Insulin doesn't cause some problems. Such as, since insulin increases glucose intake by the muscle tissues ( skeletal muscles are supposed to be used more in flight-or-fight situations ) and increases glycolysis ( which produces energy ), wouldn't decreased insulin release during flight-or-fight situations cause less glucose intake and less glycolysis ( as a result less energy production ) by the muscle tissues? And wouldn't less energy produced by the muscle tissues cause them work less efficiently?
 

Answers and Replies

  • #2
Pythagorean
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Adrenaline!

Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α1, α2, β1, β2, and β3.[15] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.[20]
http://en.wikipedia.org/wiki/Epinephrine#Mechanism_of_action

Reference [20] (a text book):

http://books.google.ca/books?id=zFl...s+of+Medical+Physiology&source=gbs_navlinks_s
 
  • #4
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Overall ongoing research also confirms that muscles can increase their glucose uptake
via other receptors or channels independent of INSULIN also.
Adrenaline pumps them up !

reference Ganong medical physiologe 23 edition.
 
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  • #5
Evo
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reference Ganong medical physiologe 23 edition.
Please post a link to the specific passage you are referencing in this book. Thank you. The book is copyrighted, so you may only quote the specific passage.
 

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