Why myeloid-erythroid ration is 4:1 while more RBC's in blood?

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The normal myeloid-erythroid ratio in the bone marrow is established at 4:1, indicating that for every erythroid cell, there are four myeloid cells. However, in circulation, red blood cells (RBCs) outnumber white blood cells (WBCs) by nearly 1000 times, which includes various non-myeloid WBCs like lymphocytes. This discrepancy can be attributed to the longer lifespan of erythrocytes, which circulate for approximately 120 days, compared to leukocytes that last only 3-4 days. Additionally, the bone marrow may maintain a reserve of myelopoietic cells for emergencies, contributing to the perceived imbalance.

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tarekatpf
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In the bone marrow, the normal ratio of myeloid and erythroid series cells is 4:1. So, for every erythroid cell, there are four myeloid cells, which gives
But in the circulation, there are almost 1000 times more RBC's than total WBC's ( which also includes non-myeloid WBC's, such as lymphocytes. )

Why is it so?
 
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tarekatpf said:
In the bone marrow, the normal ratio of myeloid and erythroid series cells is 4:1. So, for every erythroid cell, there are four myeloid cells, which gives
But in the circulation, there are almost 1000 times more RBC's than total WBC's ( which also includes non-myeloid WBC's, such as lymphocytes. )

Why is it so?

http://en.wikipedia.org/wiki/Bone_marrow

I'm not sure it is so. Myelopoietic cells constitute 56.6% of parenchymal cells while erythropoietic cells constitute 25.6% of such cells. Erythrocytes circulate for about 120 days while leukocytes circulate for about 3-4 days. This may explain part of the perceived imbalance. No teleologic explanation is required for the rest of the perceived imbalance, but it might be that the bone marrow holds a reserve of myelopoietic cells for emergencies.

EDIT: Allowing for the possibility of an error in my addition, it's still clear the ratio is closer to 2:1.
 
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