The potential of an infinite line of charge cannot be defined as zero at infinity because, unlike finite charge distributions, every point on the line has the same potential, making it impossible to set a zero reference point. As one moves away from the line, the electric field decreases inversely with distance, but the potential diverges logarithmically, preventing it from reaching zero at infinity. This behavior contrasts with finite charge configurations, where potential levels off at large distances. The discussion highlights the mathematical complexities of modeling infinite systems, emphasizing that infinite lines and planes serve as useful approximations for finite scenarios. Ultimately, the potential remains non-zero at infinity for an infinite line of charge, illustrating the limitations of applying conventional electrostatic principles to non-physical systems.