One could do some marketing to get together a group of people who would also like to attend a Science Cafe, and start one as a Co-operative/ member owned establishment (but also open to non-members.)
If there's a large enough community around you, that is...
Having a university/ college/ around would be helpful, since one can tap them for the teachers.
In my studies into History of the Colonial Era, I learned that people would group together to create things like "Mechanics Libraries", Agricultural Societies, and so forth. This was done to promote useful knowledge (as Thom. Jefferson, et al defined it) in the communities they were in. Boston, NYC, and so on.
They had books and other printed media, and when possible they would have speakers and presentations.
One could then argue that Science Cafes are a continuation of the tradition-- a high point of this heritage would be the public lectures given by James Clerk Maxwell, etc, in London every week or so at the Royal Society, or "Royal Society of London for Improving Natural Knowledge".
I think they still do this, but the whole scope of public lectures has changed with the advent of modern communications media: iUniversity, YouTube, TED talks, and the like.
http://royalsociety.org/
But it's still nice to go somewhere and be surrounded by real people who have similar interests, sort of like going to a coffeehouse or bluegrass festival. :-)
That there is a strong interest in learning science is shown in part by a new on-line course at UBC that attracted 130,000 registrants. (game theory can apply to more than just games...)
http://science.ubc.ca/
And some of the most popular websites in the world are science-oriented ones.