Bayesian statistics differs from traditional methods like t-tests by focusing on the probability of a hypothesis given observed data, rather than the probability of the data given a hypothesis. Understanding conditional probability and Bayes' Theorem is crucial for grasping Bayesian approaches. Unlike Frequentist methods, which can assign a zero probability to certain outcomes, Bayesian methods maintain a non-zero probability, reflecting prior assumptions. The discussion highlights the importance of specifying prior distributions in Bayesian analysis, particularly when dealing with continuous variables. Overall, Bayesian statistics provides a more flexible framework for inference compared to traditional statistical methods.